The present project aims at developing a biomimetic biosensor (bioFET) based on a nanowire channel field effect transistor. The device shall exploit (i) the excellent performance of nanowire field effect transistors, (ii) their particular channel geometry with high surface to volume ratios and (c) a biomimetic detection mechanism enabling sensing of low concentrations of specific target molecules. The bio-detector’s architecture will combine three key elements – (i) a high performance FET based on quasi one dimensional semiconducting nanowires; (ii) a thin film gate insulator which enables both operation in liquid/wet environment and biofunctionalization with odorant (olfactory) receptor proteins (OR) (iii) a specific bioactive functional hydrogel layer containing odorant binding proteins (OBP) with the role of locally increasing the analyte molecule concentration. Such a device will mimic living organisms smell physiology and may be an excellent tool in the fast and precise measurement and analysis of specific molecules with applications ranging from medical diagnosis to environmental monitoring. The architecture employed and the detection mechanisms will mimic olfaction by combining both odorant binding proteins and odorant receptor proteins and will aim at surpassing state of the art similar devices. A field effect transistor uses a gate potential for changing the conductance of a channel. In the particular architecture of a biodetector FET gate potential changes will be a consequence of specific binding reactions such as the reaction of OBPs with the odorant molecules or the reactions of OBP – odorant complexes with OR.