Project start date: 1.02.2026

Project completion date: 1.02.2029

Financing contract number: G8914.

Abstract

This project aims to develop new effective means, based on bioactive inorganic nanomaterials and highly active hydrogel, for the successful treatment of systemic disorders as well as wounds and burns of different origins and structures resulting from large-scale irradiation injuries. We foresee that newly fabricated formulations will possess pronounced haemostatic, antibacterial, antioxidant, and radioprotective properties. We expect reduced inflammation by adsorbing bacterial toxins, histamine, reactive oxygen species (ROS), and products of lipid and protein oxidation/peroxidation. The fulfilment of planned activities will enable us to propose an algorithm for constructing a novel biocompatible combined 'smart' gel enterosorbent (CSE) and combined 'smart' applicator (CSA) to treat systemic disorders and skin lesions in victims of large-scale radiation injuries. The positive results of the project and the practical confirmation of the effectiveness and feasibility of the developed formulations for the treatment of irradiation damages will allow them to be used for effective therapy of systemic disorders in the body as well as rapid wound care, including the treatment of contaminated, infected deep wounds and severe burns typical irradiation victims.