Acronym: SYSDELBIO

Contract number 63PED/2025

PN-IV-P7-7.1-PED-2024-2569

Teams/Parteneri:

• Coordinator/Coordonator - National Institute of Materials Physics, NIMP (Institutul Național de Cercetare Dezvoltare pentru Fizica Materialelor, INCDFM) (www.infim.ro)

• Partner/Partener - Biotehnos SA (https://biotehnos.ro/)

The need to identify new therapeutic approaches in the management of skin wounds has initiated new R&D strategies that explore emerging technologies to achieve therapeutic solutions with an effective healing process. This project proposes the design and preparation of a delivery system with time-release, being made of substrates (e.g. plastic foils and 3D printed porous bodies) loaded with polymeric coatings containing biocompatible, biodegradable, and bioactive ingredients. New combinations of active ingredients such as protease enzymes, MgB₂ and plant extracts with a standardised phytocompound content (flavones, polyphenols and phenols) from the Asteraceae family are used in these systems. The proposed combination is expected to exhibit synergistic or cumulative healing effects, providing multiple functionalities, e.g. antimicrobial, anti-inflammatory, regenerative, balancing, analgesic, others. Depending on the sequence and release timing of the active components of the delivery system, they will act efficiently and in an adapted manner versus specifics and condition of the wound which can have a wide spectrum of injury and healing stages.