Improving the biointegration of cranio-spinal implants by bioactive multilayers coatings (BIOSTIMP)


Project Director: Dr. George Stan

Project ID: PN II 71-110/2007

Project Responsible P1: Dr. George Stan

Project Type: National

Project Program: PCCA

Funded by: Romanian Ministry of Education and Research

Contractor: Grigore T. Popa University of Medicine and Pharmacy, Iasi

Sub-Contractor: National Institute of Materials Physics (P1)

Project Status: Finished

Start Date: 1 October, 2007

End Date: 1 December, 2010

 

Project summary: 

Functionalized surfaces implants represent the most advanced trend in implantology. Hydroxyapatite coatings of cranio-spinal implants is the subject of the most recent research in the atempt to improve their biointegration. The present project aims at matching the current results of the most advanced reasearch laboratories and clinics in the field of neurosurgical implantology. To achieve this goal various types of metal and polymer cranio-spinal implants (plates, screws, cages, switches) will be coated with osteoinductive HA films applied through advanced techniques such as Pulsed Laser Deposition (PLD) and Magnetron Sputtering (MS). The resulting functional implants will be characterized from the point of view of their physical and chemical properties through SEM, XRD and FTIR. To assess their biointegration properties before the clinical stage we will use osteoblast cells cultures and explants obtained from the anatomical areas targeted for implantation. The biological response will be evaluated by studying the explants integration with the in vitro generated cell cultured surfaces. Clinical testing will be conducted for a number of carefully chosen pathology and surgical operations. Several comparative studies will be performed for various patients lots depending on the specific pathology (cranial, cervical, thoracic, lumbar) and types of implants (functionalized and non-functionalized) in order to fully assess the biointegration capability of the HA films. This project opens new possibilites to construct neurosurgical implants with superior biointegration properties that will lead to a significant improvement of the present surgical techniques and will play a major role in improving the quality of life for the targeted patients.

 

Project Objectives: 

GENERAL OBJECTIVES:

  • to develop novel medical techniques and to improve the efficiency of the public health system;
  • to develop new bio-materials, products, and production routines with a high collateral value.

SPECIFIC OBJECTIVES:

  • bone-integrating coatings on large surfaces of metal (titanium, stainless steel) and PMMA;
  • functional coatings with adhesion buffer layer onto metallic implants (adherence of 90 MPa on metal, compared with 20-30 MPa values generally recorder for plasma spray coatings);
  • in vitro studies (cellular cultures and explants) to assess the toxicity and bone-integration capability of HA coatings;
  • to perfect surgical procedures/techniques for comparative clinical testing of functional implants versus classical, uncoated implants;
  • to study the effect of coating the titanium, stainless steel, and PMMA implants with a biocompatible layers of HA on the implant osteintegration on short-, medium-, and long-term.
Name SURNAMEPROJECT POSITIONTASKS
Constantin MOROSANUProject responsible

2007-2009

  • magnetron sputtering
  • XRD
George STANProject responsible

2009-2010

  • magnetron sputtering
  • SEM
  • XRD
  • bioactivity assays
Iuliana PASUKTeam member
  • XRD, XRF
  • SEM
Cristian TEODORESCUTeam member
  • XPS, AES
Mihai POPESCUTeam member
  • XRD
Ionut ENCULESCUTeam member
  • Defects in solids
Mihai VLAICUTeam member
  • XRD, XRF
  • XSAFS
  • XPS
Tionica STOICATeam member
  • sol-gel deposition
Carmen PLAPCIANUTeam member
  • oxide technology
Dan MARCOVTeam member
  • magnetron sputtering
  • bioactivity assays
Cristina BESLEAGATeam member
  • magnetron sputtering
Catalin RADULESCUTeam member
  • electronic engineering
Petre COSMATeam member
  • mechanical engineering

Web of Science® articles:

  • 01. G.E. Stan*,^, C.O. Morosanu^, D.A. Marcov^, I. Pasuk^, F. Miculescu, G. Reumont, Effect of annealing upon the structure and adhesion properties of sputtered bio-glass/titanium coatings,  APPL SURF SCI 255 (2009) 9132–9138; doi: 10.1016/j.apsusc.2009.06.117.
  • 02. G.E. Stan*,^, Adherent functional graded hydroxylapatite coatings produced by sputtering deposition techniquesJ OPTOELECTRON ADV M 11 (2009) 1132–1138; http://joam.inoe.ro/index.php?option=magazine&op=view&idu=2011&catid=41
  • 03. G.E. Stan*,^, S. Pina, D.U. Tulyaganov, J.M.F. Ferreira, I. Pasuk^, C.O. Morosanu^, Biomineralization capability of adherent bio-glass films prepared by magnetron sputteringJ MATER SCI-MATER M 21 (2010) 1047–1055; doi: 10.1007/s10856-009-3940-9.
  • 04. G. Socol, A.M. Macovei, F. Miroiu, N. Stefan, L. Duta, G. Dorcioman, I.N. Mihailescu*, S.M. Petrescu, G.E. Stan^, D.A. Marcov^, A. Chiriac, I. Poeata, Hydroxyapatite thin films synthesized by pulsed laser deposition and magnetron sputtering on PMMA substrates for medical applicationsMATER SCI ENG B-ADV 169 (2010) 159–168; doi: 10.1016/j.mseb.2010.01.011.
  • 05. C. Berbecaru*, H.V. Alexandru, G.E. Stan^, D.A. Marcov^, I. Pasuk^, A. Ianculescu, First stages of bioactivity of glass-ceramics thin films prepared by magnetron sputtering techniqueMATER SCI ENG B-ADV 169 (2010) 101–105; doi: 10.1016/j.mseb.2010.01.007.
  • 06. G.E. Stan*,^, D.A. Marcov^, I. Pasuk^, F. Miculescu, S. Pina, D.U. Tulyaganov, J.M.F. Ferreira, Bioactive glass thin films deposited by magnetron sputtering technique: The role of working pressureAPPL SURF SCI 256 (2010) 7102–7110; doi: 10.1016/j.apsusc.2010.05.035.
  • 07. G.E. Stan*,^, A.C. Popescu, I.N. Mihailescu, D.A. Marcov, R.C. Mustata, L.E. Sima, S.M. Petrescu, A. Ianculescu, R. Trusca, C.O. Morosanu^, On the bioactivity of adherent bioglass thin films synthesized by magnetron sputtering techniquesTHIN SOLID FILMS  518 (2010) 5955–5964; doi: 10.1016/j.tsf.2010.05.104.
  • 08. L.E. Sima, G.E. Stan^, C.O. Morosanu^, A. Melinescu, A. Ianculescu, R. Melinte, J. Neamtu, S.M. Petrescu*, Differentiation of mesenchymal stem cells onto highly adherent RF sputtered carbonated hydroxylapatite thin filmsJ BIOMED MATER RES A 95 (2010) 1203–1214; doi: 10.1002/jbm.a.32947.
  • 09. L. Duta*, G. Socol, F. Sima, I.N. Mihailescu, G.E. Stan^, D.A. Marcov^, L.E. Sima, S.M. Petrescu, A. Melinescu, A. Ianculescu, A. Chiriac, I. Poeata, Increased bioactivity of cranio-spinal implants functionalized with hydroxyapatite nanostructured coatings: morpho-structural characterization and in-vitro evaluationIEEE, ISBN: 978-1-4244-8842-1, Advanced Technologies for Enhancing Quality of Life (AT-EQUAL) Conference, Iasi, (IEEE, 2010), pp. 127–130, 2010; doi: 10.1109/ATEQUAL.2010.27.
  • 10. A. Chiriac, G.E. Stan*,^, B. Iliescu, I. Poeata, The influence of host bone substrate in titanium mesh cranioplastyDIG J NANOMATER BIOSTRUCT 8 (2013) 729–735; http://www.chalcogen.infim.ro/729_Chiriac.pdf.

 

Patents:

01. A. Chiriac, L. Duta, A. Ianculescu, I.N. Mihailescu, M.  Miroiu, S. Petrescu, A. Popescu, I. Poeata, F. Sima, G. Socol, G.E. Stan^; Ti mesh implants biofunctionalized with hydroxyapatite nanostructured thin layers for cranioplasty; OSIM patent, RO 128190 B1, awarded 2014-04-30.

 

*corresponding author
^project team member

 

Sub-contractor P1:
GEORGE E. STAN, PhD in Materials Engineering
Senior Researcher I
Telephone: +40-(0)21-2418 128 or +40-(0)21-2418 153
Department: Laboratory of Multifunctional Materials and Structures


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