Advanced biodegradable materials based on MgB2 resistant to microbial colonization


Project Director: Dr. Petre BADICA

Project ID:

Project Code: COFUND-M-ERA.NET II-BIOMB (Romania), Contract No.: 74 / 14.06.2017 (Romania), Acronym: BIOMB

Project Director:

Dr. P. Badica

Project Type:

International

Project Program:

M-ERA.NET

Contractors:

Partners from Romania

1. Coordinator: National Institute of Materials Physics: (www.infim.ro) P. Badica

2. Partener 1: University ’Politehnica’ of Bucharest (UPB): (http://www.upb.ro/; http://sim.pub.ro/; http://expertizari.wixsite.com/cems-upb) D. Batalu

3. Partener 2: University of Bucharest (UB): (http://www.unibuc.ro/; http://www.bio.unibuc.ro C.M. Chifiriuc

FUNDING ORGANIZATION: UEFISCDI; European Commission

Partner from Italy

1. Partener 3: Torino University: (https://www.unito.it/; http://www.df.unito.it/do/home.pl; http://www.solid.unito.it/) M. Truccato

FUNDING ORGANIZATION: MIUR, European Commission

Project Status:

In progress

Start Date:

6 June, 2017

End Date:

The project was extended from 14 May, 2020 to 31 July 2021 due to COVID-19

Project Abstract:

The innovation of this project consists in the evaluation for the first time of the MgB2 potential for biomedical applications, although it is currently produced for superconductivity devices. Expectations are to generate new MgB2-based composite multifunctional biomaterials with antimicrobial/antifouling properties, and an increased biocompatibility at interfaces between the material and the biological media. The mechanical and physical-chemical properties of the proposed materials as poweders, coatings, and bulks will be investigated by a comprehensive approach, and bioevaluation will include in vitro and in vivo assays. The MgB2 materials are viewed as solutions for space and time- scale controlled variation of the functional properties required for different bio-applications.

Project Objectives:

Higher standards of living and improvements in medicine led to an increase in life expectancy, correlated with a continuing greater demand for medical devices. The Global Industry Analysis and Forecast 2016 – 2024 predicts that the biomaterials market will reach 120 Billion Euro by 2020. However, the more and more frequent, prolonged use of medical devices has been linked to an increased risk related to biofilm associated infections. As a consequence of these chronic, persistent and hard to treat infections, healthcare budgets increase, hospital stays are prolonged and patients’ mortality and morbidity are higher. In this context, the prevention and eradication of biofilm infections represents a real challenge for materials science.

Taking these facts into account we consider appropriate to conduct a multidisciplinary research project, proposing a new solution for improved/safer biomaterials.

The BIOMB project is a concerted endeavour of ROMANIA and ITALY to conduct mechanical, physico-chemical and biological investigations of new Mg-based composite materials for biomedical applications. Designing biomaterials and medical devices with increased resistance to microbial colonization without impairing their biocompatibility is the main aim of our project. In this endeavour, a complex methodological approach will be used in order to provide improved biomaterials with optimum mechanical and biocompatibility properties and with the ability to resist microbial colonization and subsequent biofilm development.

The general objective of the project is fabrication of materials based on MgB2 and exploration of the properties targeting biomedical applications.

The project is structured into the following work packages, WP:

WP I, Responsible researcher: G. Aldica

Physico-chemical characterization of MgB2 powders and of other raw materials (additives, adhesives, others)

WP II, Responsible researcher: M.C. Chifiriuc

In vitro bioevaluation of materials from WP I

WP III, Responsible researcher: G. Aldica

Fabrication of bulk samples of MgB2 with and without additives

WP IV, Responsible researcher: D. Batalu

Physico-chemico-mechanical-degradable characterization of bulks obtained at WP III

WP V, Responsible researcher: C. Bleotu

In vitro and in vivo bioevaluation of materials from previous WP (biocompatibility, microbicidal and anti-biofilm properties

WP VI Responsible researcher: D. Batalu

Powders and coatings for applications (powder+additive+liquid carrier & adhesive + propellant) with MgB2 or other powder/coated medical devices/applications). Composite polymer-MgB2 wires for 3D printing

WP VII Responsible researcher: A. Agostino

MgB2 bulks for applications

WP VIII Responsible researcher: P. Badica, M. Truccato

The project management and dissemination of the scientific results

ROMANIA

1Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RABADICA PetreDirector
2Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTIBATALU Nicolae DanResponsible of the Partner (1)
3Partener (P2) - UNIVERSITATEA BUCURESTICHIFIRIUC Mariana CarmenResponsible of the Partner (2)
4Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAALDICA Gheorghe VirgilResearcher
5Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAVLAICU Aurel MihailResearcher
6Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAENCULESCU MonicaResearcher
7Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RASANDU ViorelResearcher
8Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAMIU LucicaResearcher
9Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RACRISAN AdrianResearcher
10Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RACOSTESCU RuxandraResearcher
11Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAIVAN IonResearcher
12Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAKUNCSER AndreiResearch Assistant
13Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RABURDUSEL MihailResearch Assistant (PhD student)
14Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAIONESCU Alina MarinelaResearch Assistant (PhD student)
15Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAGRIGOROSCUTA Mihai AlexandruResearch Assistant (PhD student)
16Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RALECA AurelMaintenance Engineer
17Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RAIACOB NicusorMaintenance Engineer
18Coordonator (CO) - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RABARTHA CristinaResearcher
19Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTIGHEORGHE DanResearcher
20Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTICIOCOIU RobertPost-doc
21Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTIBOLOLOI RobertPost-doc
22Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTICOJOCARU Vasile DanutResearcher
23Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTITRANTE OctavianResearcher
24Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTIBUNESCU AnamariaResearch Assistant
25Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTIMICULESCU FlorinResearcher
26Partener (P2) - UNIVERSITATEA BUCURESTILAZAR VeronicaResearcher
27Partener (P2) - UNIVERSITATEA BUCURESTIPOPA MarcelaResearcher
28Partener (P2) - UNIVERSITATEA BUCURESTISTOICA MariaTechnical personnel
29Partener (P2) - UNIVERSITATEA BUCURESTICOSTACHE LilianaTechnical personnel
30Partener (P2) - UNIVERSITATEA BUCURESTISARBU Ecaterina MonicaResearcher
31Partener (P2) - UNIVERSITATEA BUCURESTIBARBU IldaResearcher
32Partener (P2) - UNIVERSITATEA BUCURESTIMARUTESCU LuminitaResearcher
33Partener (P2) - UNIVERSITATEA BUCURESTIGHEORGHE IrinaResearcher
34Partener (P2) - UNIVERSITATEA BUCURESTIHOLBAN AlinaResearcher
35Partener (P2) - UNIVERSITATEA BUCURESTICURUTIU CarmenResearcher
36Partener (P2) - UNIVERSITATEA BUCURESTIDITU Lia MaraResearcher
37Partener (P2) - UNIVERSITATEA BUCURESTIGRADISTEANU GratielaResearcher
38Partener (P2) - UNIVERSITATEA BUCURESTIPANA MariaResearcher
39Partener (P2) - UNIVERSITATEA BUCURESTISORICILA GratielaResearch Assistant
40Partener (P2) - UNIVERSITATEA BUCURESTIGRIGORE MihaescuResearcher
41Partener (P2) - UNIVERSITATEA BUCURESTIBLEOTU CoraliaResearcher
42Partener (P2) - UNIVERSITATEA BUCURESTITURLEA JaninaResearcher
43Partener (P1) - UNIVERSITATEA POLITEHNICA DIN BUCURESTITRANCAU OvidiuResearch Assistant

ITALY

Under construction

The end of the project was extended to July 31, 2021.

see Romanian website https://infim.ro/project/biomb/

BSc:

  1. Bunescu Anamaria (supervisor Batalu Dan, UPB): Technology for obtaining a polymeric composite for 3D printing (2018).

  2. Copoiu Ștefan (supervisor Batalu Dan, UPB): Use of auxetic materials in medical engineering (2018).

  3. Modiga Aida Andrada (supervisor Batalu Dan, UPB): Studies on the design of corneal implants (2018).

  4. O Cristea (supervisor I Gheorghe, UB): Characterization of filamentous microscopic fungal strains isolated from lovrin wheat caryopsis (2019);

  5. Andrei Cosmin Roznov (supervisor D Batalu): Study on digital processing and the use of PMMA in 3D printing with applications in dentistry (2019);

  6. Roxana Georgiana Saveli (supervisor D Batalu): Design of a robotic finger (2019).

MSc:

  1. M Lupsa (supervisor MC Chifiriuc, UB): Aspects regarding the virulence and antibiotic resistance of some microbial strains involved in oral pathology (2019);

  2. DS Copoiu (coordonator MC Chifiriuc, UB): The microbial activity of nanoparticles on some species of filamentous fungi isolated from cultural heritage objects (2019);

  3. Octavia Emilia Zetu (supervisor Irina Gheorghe, UB), Biodiversity of filamentous microscopic fungi involved in the process of biodeterioration of stone cultural heritage objects and new strategies for their preservation and restoration (2020)

  4. Andreea Dumbrava (supervisor Irina Gheorghe), Complex analysis of filamentous microscopic fungal strains involved in the biodeterioration of wooden heritage churches in Arad, Hunedoara and Bucharest counties (2020)

  5. Bunescu Anamaria (supervisor D. Batalu, UPB), Advanced design through topological optimization and 3D printing with applications in the aeronautical industry (2020).

PhD:

  1. Othman Thamer Al-mahdawy (supervisor MC Chifiriuc, UB) Virulence and resistance markers in Gram-positive cocci of clinical importance (2019);

Journals

  1. P. Badica, D. Batalu, M. Burdusel, M.A. Grigoroscuta, G. V. Aldica, M. Enculescu, R.A. Gabor, Z. Wang, R. Huang, P. Li, Compressive properties of pristine and SiC-Te-added MgB2 powders, green compacts, and Spark Plasma Sintered bulks, Ceram. Int. 44 (2018) 10181-10191 (doi:10.1016/j.ceramint.2018.03.008)

  2. D. Batalu, F. Nastase, M. Militaru, M. Gherghiceanu, P. Badica, NiTi coated with oxide and polymer films in the in vivo healing processes, 2018, in press (doi: https://doi.org/10.1016/j.jmrt.2018.06.015)

  3. Laura Gozzelino, Roberto Gerbaldo, Gianluca Ghigo, Daniele Torsello, Valentina Bonino, Marco Truccato, Mihai A Grigoroscuta, Mihail Burdusel, Gheorghe V Aldica, Viorel Sandu, Iuliana Pasuk, Petre Badica, High magnetic shielding properties of an MgB2 cup obtained by machining a spark-plasma-sintered bulk cylinder, SUST 33 (2020) 044018 (https://doi.org/10.1088/1361-6668/ab7846).

  4. M. A. Grigoroscuta, G. Aldica, I. Pasuk, M. Burdusel, V. Sandu, A. Kuncser, T.S. Suzuki, O. Vasylkiv, P. Badica, Partially-oriented MgB2 superconducting bulks with addition of B4C and cubic BN obtained by slip casting under high magnetic field and spark plasma sintering, Mater. Res. Bull. 134 (2021) 111103 (https://doi.org/10.1016/j.materresbull.2020.111103).

  5. M. A. Grigoroscuta, V. Sandu, A. Kuncser, I. Pasuk, G. Aldica, T.S. Suzuki, O. Vasylkiv, P. Badica, Superconducting MgB2 textured bulk obtained by ex situ spark plasma sintering from green compacts processed by slip casting under a 12T magnetic field, SUST 32 (2019) 125001 (https://doi.org/10.1088/1361-6668/ab4620).

  6. Frone AN, Batalu D, Chiulan I, Oprea M, Gabor AR, Nicolae CA, Raditoiu V, Trusca R, Panaitescu DM, Morpho-Structural, Thermal and Mechanical Properties of PLA/PHB/Cellulose Biodegradable Nanocomposites Obtained by Compression Molding, Extrusion, and 3D Printing. NANOMATERIALS 10 (2020) 51 (doi: 10.3390/nano10010051).

  7. Irina Gheorghe, Ionela Avram, Viorica Matis Corbu, Luminita Măruțescu, Marcela Popa, Irina Balotescu, Ion Blăjan, Venus Mateescu, Andreea Ștefania Dumbravă, Octavia Emilia Zetu, Ionut Pecete, Violeta Corina Cristea, Dan Nicolae Batalu, Mihai Alexandru Grigoroscuta, Mihail Burdusel, Gheorghe Virgil Aldica, Petre Badica, Adina Daniela Datcu, Nicoleta Ianovici, Coralia Bleotu, Veronica Lazar, Lia Mara Dițu, Mariana Carmen Chifiriuc, In vitro evaluation of MgB2 powders as novel tools to fight fungal biodeterioration of heritage buildings and objects, submitted

  8. P. Badica, N.D. Batalu, M.C. Chifiriuc, M. Burdusel, M.A. Grigoroscuta, G. Aldica, I. Pasuk, A. Kuncser, M. Enculescu, M. Popa, L.G. Marutescu, I. Gheorghe, O. Thamer, C. Bleotu, G. Gradisteanu Pircalabioru, L. Operti, V. Bonino, A. Agostino, M. Truccato, Promising new inorganic materials to approach old medical challenges: bioevaluation of MgB2 powders interaction with planktonic microbes, biofilms and tumor cells, submitted

  9. P. Badica, N.D. Batalu, M. Burdusel, M.A. Grigoroscuta, G. Aldica, M. Enculescu, G. Gradisteanu Pircalabioru, M. Popa, L.G. Marutescu, B.G. Dumitriu, L. Olariu, A. Bicu, B. Purcareanu, L. Operti, V. Bonino, A. Agostino, M. Truccato, and M.C. Chifiriuc, In vitro assay of the MgB2 powders cytocompatibility and antibacterial activity of MgB2-PVP biodegradable self-replenishing coatings against bacteria in planktonic and biofilm growth state, submitted.

Book chapters

  1. Tribot, D. Batalu, C. Brasselet, C. Delattre, L. Wei, J. Lao, P. Badica, P. Michaud, H. de Baynast. Green polymers filaments for 3D printing, book chapter, Springer (accepted, to be published in 2021).

Patents:

  1. P. Badica, D. Batalu, M. A. Grigoroscuta, M. Burdusel, G. V. Aldica, M. Popa, M. C. Chifiriuc, “Pulberi, corpuri sinterizate și acoperiri pe bază de MgB2 rezistente la colonizarea microbiană și cu eficiență împotriva biofilmelor microbiene și metodă de folosire a acestora”, cerere brevet OSIM, A 2018 01129 (20.12.2018)

  2. D.N. Batalu, A. Bunescu, P. Badica, Material compozit functional cu matrice din polimer si adaos de pulbere MgB2, cerere brevet OSIM A 2020 00405 (15.07.2020)

Conferences:

2017

(1) D. Batalu, F. Nastase, M. Militaru, M. Gherghiceanu, L. Moldovan, M. Bucur, G. Aldica, P. Badica, New materials and devices for biomedical applications, International Union of Materials Research Societies - The 15th International Conference on Advanced Materials (IUMRS-ICAM), August 27-September 1, 2017, Kyoto, Japonia (invited).

2018

(1) Alina Sîrghi, Irina Gheorghe, Luminița Marutescu, Dan Batalu, Petre Badica, Badea Mihaela, Rodica Olar, Omar Sadik, Gyath Aldin Aziz, Ionela Avram, Zhiyong Zong, Mariana Carmen Chifiric, Activity of different inorganic nanoparticles against fungal isolates colonising buildings included in the Romanian National Heritage, First Balkan Conference of Medical Mycology and Mycotoxicology – Balkan Fungus 2018, Timisoara, Romania, 13-15 September 2018 (oral).

(2) Othman Thamer Almahdawy, Petre Badica, Dan Batalu, Irina Gheorghe, Marcela Popa, Omar Sadik Shalal, Dunya Alkurjia, Otilia Banu, Luminita Marutescu, Grigore Mihaescu, Carmen Chifiriuc, In vitro activity of novel inorganic nanoparticles based on halogenatedmagnesium salts on MRSA cells in planktonic and adherent growth state, P2188. 22th ECCMID, 24-28 April, Madrid, Spain (poster).

(3) D. Batalu, A. Bunescu, P. Badica, Assessment of some new polymeric composites used for 3D printing, 18th European Conference on Composite Materials, Athens, Greece, June 24- 28, 2018 (poster).

(4) D. Batalu, A. Bunescu, M. Popa (Bucur), L. Marutescu, M.C. Chifiriuc, P. Badica, Assessment of Antibacterial Behavior of some Polymer Composites used for 3D printing, 4th International Conference on Biomedical Polymers & Polymeric Biomaterials, Krakow, Poland, July 15- 18, 2018 (poster).

(5) N. Pons, A. Bunescu, P. Badica, D. Batalu, New Polymeric Composite for 3D printing, 14th International Symposium PRIOCHEM, Bucharest, Romania, October 10-12, 2018 (poster).

2019

(1) P Badica, MgB2-based materials for different applications, VI International Conference of Technical Chemistry from Theory to Praxis, 21-23 May 2019, Perm, Russia (invitata)

(2) P Badica, M Burdusel, MA Grigoroscuta, G Aldica, DN Batalu, M Bucur, C Chifiriuc, MgB2 based materials for the improvement of life quality, 2nd European ONE HEALTH Conference, 21-22 Iunie 2019, Bucuresti, Romania (oral)

(3) D Batalu, A Bunescu, P Badica, Z Xiang, W Lu, New composites for additive manufacturing, The 10th Pacific Rim International Conference on Advanced Materials and Procesing (PRICM 10) 18-22 Aug 2019, Xi’an, China (oral)

(4) GV Aldica, D Batalu, P Badica, Thermal analysis on Ga or In acetylacetonate powders, 5th Central and Eastern European Conference on Thermal Analysis and Calorimetry & 14-th Mediterranean Conference on Calorimetry and Thermal Analysis, 27-30 Aug 2019, Roma, Italy (poster)

(5) OT Almahdawy, P  Badica, D Batalu, I Gheorghe, M Popa, O Sadik Shalal, D Alkurjia, O Banu, L Măruţescu, G Mihăescu, C Chifiriuc. In vitro activity of novel inorganic nanoparticlesbased on halogenated magnesium salts on MRSA cells in planktonic and adherent growth state, 28th European Congress of Clinical Microbiology and Infectious Diseases, 21-24.04.2018, Madrid, Spania (Poster).

2020

1. O serie de conferinte internationale/nationale planificate in 2020 au fost anulate sau amanate pentru 2021.

2. Viorica Corbu, Irina Gheorghe, Luminita Măruțescu, Marcela Popa, Irina Balotescu, Ion Blăjan, Venus Mateescu, Andreea Dumbravă, Octavia Zetu, Ionut Pecete, Violeta Cristea, Dan Batalu, Petre Badica, Nicoleta Ianovici, Coralia Bleotu, Veronica Lazar, Lia Mara Dițu, Carmen Chifiriuc. Activitatea antimicrobiană a nanoparticulelor de MgB2 asupra unor microfungi izolați de pe obiecte de patrimoniu cultural. Sesiunea de Comunicări Ştiințifice „D. Brandza” Ediția a-XXVI-a (oral).

Visits

1. P. Badica delivered at Torino University two presentations:

(a) State of the art in the project ERA-M 74/2017 BIOMB

(b) Advanced biodegradable materials based on MgB2 resistant to microbial colonization (2018)

2. P. Badica visited Torino University: experiments were performed for the synthesis and characterization of materials in the Mg-B system (2019).

3. The visit of the student Nicoletta Baglieri from Univ. from Turin to Bucharest (ERASMUS ++ scholarship) was canceled due to the COVID-19 pandemic (2020).

4. D. Batalu – visit to the company Recond Expert SRL, Baia Mare, 19-23 februarie (2020).

Project Contact Person:

ROMANIA

BADICA Petre

National Institute of Materials Physics, street Atomistilor 405A, 077125 Magurele, Ilfov, ROMANIA

Fax: +40-21-3690177, Ph: +40-213690185

ITALY

TRUCCATO Marco

Physics Dept. - University of Torino via P. Giuria 1, 10125 Torino - Italy

Fax:+39 011 6707020, Ph: +39 011 6707374


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