Molecularly imprinted nanofluidic biosensors for the detection of human derived proteins


Project Director: Dr. Monica ENCULESCU

Molecularly imprinted nanofluidic biosensors for the detection of human derived proteins project (MINaFBioS) intends to develop nanofluidic architectures embedded within nanoelectrodes in order to fabricate a biosensor for human proteins. MINaFBioS will simulate nanofluidic architectures of assemblies of conducting polymers doped with ceramic nanotubes able to enhance optimal delivery of the target molecule from the bulk solution to the sensing surfaces. The project will perform 2D and 3D design of nanofluidic architectures associated to ceramic nanotubes assemblies’ technology and formulate recommendation for micro-manufacturing. Physico-chemical characterization of the nanofluidic architectures associated to ceramic nanotubes assemblies will be performed. MINaFBioS will use, for generating the nanochanels features, special ceramic nanotubes and their assemblies to be produced and tailored by the project partners and used for biosensors applications. The project will develop tailored electrodes by assembling conducting polymers doped with ceramic nanotubes with tailored nanofluidic features and graphene. The project intends to associate the assemblies of conducting polymers and graphene, and to generate specificity to certain human derived proteins. MINaFBioS will perform the electrochemical simulation, design and evaluation of integrated nanofluidic sensing technology and achieve the laboratory proof of concept. Finally, the project will develop a biological sensor for the detection of human derived proteins with innovative aiming to develop and to validate at laboratory level.

 

SPANISH PARTNERS:

Partner (P3) MATEPRINCS SL (Small-medium enterprise)

Contact person: José Ignacio Oteiza

Partner (P4) NAITEC (FUNDACION I+D AUTOMOCION Y MECATRONICA) (Private Research Centre)

Contact person: Aaron Cabrera 

Funded by: Government of Navarra. Department of Economic Development (Spain/Navarra)

Simulation of nanofluidic architectures and microfabrication technology of ceramic nanotubes as the composites’ support for integrating nanofluidic features.

Design and fabrication of electrodes based on composites from conductive polymers doped with ceramic nanotubes and graphene.

Optimization of design and tehnology of fabrication of the integrated nanoelectrodes for biofunctionalization with proteins.

Laboratory proof of concept and optimization of biosensor based on nanofluidic architectures.

Demonstrative report for functional validation of the biosensor using peptides.

Patent of the biosensor based on nanofluidic architectures.

1.Graphene oxide concentration effect on the optoelectronic properties of ZnO/GO nanocomposites

Nanomaterials 2020, 10(8), 1532; https://doi.org/10.3390/nano10081532

I. Boukhoubza,  M. Khenfouch, M. Achehboune, L. Leontie, A.C. Galca, M. Enculescu, A. Carlescu, M. Guerboub, B.M. Mothudi, A. Jorio, I. Zorkani 

 

2.

Validation of an innovative electrochemical sensor for human derived proteins based electrodes consisting of nanofluidic architectures, fabricated using conductive polymers doped with ceramic nanotubes and graphene, embedded in electrodes.

Monica Enculescu

Email: mdatcu@infim.ro


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