Publications

Herein, Cu(II)-doped SrSnO3 perovskites (SrSn1-x Cu x O3, namely SSO:Cux) were prepared by a modified Pechini method and applied as supercapacitors (SCs) for the first time. The effect of dopant concentration (x = 1, 2.5, and 5 mol %) was investigated to fine-tune the structural and electronic properties to design potential candidates as SCs. The SSO:Cux samples were characterized by conventional XRD and synchrotron XRD (S-XRD) combined with Rietveld refinements and spectroscopic analyses, such as Raman, FTIR, UV-vis, EPR, and XANES/NEXAFS. The electrochemical performance of the SSO:Cux samples was investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and galvanostatic cycling with potential limitation (GCPL). It was evidenced that incorporating 2.5 mol % Cu(II) into the SrSnO3 perovskite lattice (SrSn0.975Cu0.025O3, SSO:Cu2.5) led to a significant change in structural disorder and electronic properties, which play an essential role in creating a mixture of point defects such as reduced Sn3+ and Cu+ cations, and oxygen vacancies (VO). The SC device constructed with the SSO:Cu2.5 material showed a specific capacitance of 613 F g-1 at a scan rate of 1 mV s-1, with a remarkable specific energy density and specific energy power of 25.42 W h kg-1 and 32678.57 W kg-1, respectively, which are higher than those observed for any other available perovskite-based SCs. This performance was primarily attributed to the formation of mixed Sn4+/Sn3+ and Cu2+/Cu+ cations, which alter the structural and electronic properties of SrSnO3. Our findings indicate that an improved capability to store high energy and power may be achieved by fine-tuning the Cu(II) dopant concentration in the lattice and controlling the formation of undesired phases. This offers experimental guidance to design other Cu-doped perovskites as alternative materials for energy storage applications.

This study covers three complementary aspects; it focuses first on analyzing the turn-on and turn-off processes of the power CoolMOS transistor and investigating its switching times. Furthermore, it expands the scope of our previous works by validating the dynamic behaviour of the proposed model of the power CoolMOS transistor and it assesses the influence of the external gate resistance on the device's switching performance. Simulation results for the switching characteristics were verified through experimental measurements. An experimental test was carried out using a resistive load circuit with different external gate resistance values to analyze its impact on the device's switching behavior. The findings confirm the accuracy of the conclusions drawn from the theoretical and simulation analyses presented in this paper.

We report the synthesis and characterization of folic acid (FA)-conjugated human serum albumin nanoparticles, (HSA-FA):Ru NPs, as targeted carriers for rutin (Ru), a flavonoid with known anticancer activity. Nanoparticles were fabricated via a desolvation method, and their surface was functionalized with folic acid to promote selective uptake by cancer cells overexpressing folate receptors. Morphological and dimensional analyses performed by atomic force microscopy (AFM), scanning electron microscopy (SEM), and fluorescence microscopy confirmed that all nanoparticles were below 100 nm and exhibited good colloidal stability. Voltametric measurements confirmed the successful incorporation of both rutin and folic acid within the (HSA-FA):Ru nanoparticle formulation. Biological evaluation was conducted on healthy L929 fibroblasts and HT-29 colon adenocarcinoma cells. MTS colorimetric assays revealed that (HSA-FA):Ru NPs significantly reduced the viability of HT-29 cells, while maintaining higher compatibility with L929 cells. Fluorescence and electron microscopy further confirmed preferential nanoparticle uptake and surface accumulation in HT-29 cells, supporting the role of folic acid in enhancing targeted delivery. The study demonstrates that HSA-based nanoparticles functionalized with FA and loaded with Ru offer a biocompatible and efficient strategy for selective intracellular drug delivery in colorectal cancer. These findings support the use of albumin-based nanocarriers in the development of targeted therapeutic platforms for cancer treatment.

The crystallization mechanism of Yb/Er-doped GdF3 nanocrystals in silica nano-glass ceramics was analyzed using model-free and model-fitting methods and thermal analysis data in correlation with structural data. The formation of GdF3 nanocrystals occurs at around 300 degrees C, and their size is temperature dependent, ranging from 14 to 40 nm, depending on the processing temperature. A similar trend is observed for cell volume, where a contraction of up to approximate to 2.3% (at 600 degrees C) was assigned to the gradual incorporation of Li and Yb,Er dopants. Model-free analysis showed an increase in activation energy (Ea) and the preexponential factor (log A) up to 175 kJ mol-1 and 14.8 s-1, respectively, until the completion of crystallization. Model-fitting analysis indicated a crystallization process controlled by an autocatalytic-type reaction where a second metastable phase (LiF) acts as a catalyst and facilitates a rapid and self-accelerated crystallization of the main GdF3 nanocrystalline phase. The ceramization process boosted UC luminescence up to values comparable to those of NaYF4:18Yb/2Er.

Due to the importance of buffer layers in interface engineering, the development of more variants and the rational design of materials have a significant influence on the performance of optoelectronic devices. This study provides a strategy to increase device performance by facilitating efficient charge transfer and defect passivation by combining the properties of eco-friendly materials (adenine, cytosine, guanine, thymine, and uracil) with the physicochemical properties of metal oxides. The aim of this paper was to investigate the interaction of zinc oxide (ZnO) nanostructures (seed, nanoparticles, and nanowires) with nucleobase layers and to discuss their potential applications as organic-inorganic interfacial bilayers. The impact is analyzed from structural, morphological, optical, and electrical points of view. Nucleobase-ZnO nanostructure layers present high optical transparency in the visible range. Electrical measurements confirmed that the high surface area of nanowires can enhance interactions with nucleobases, leading to better charge transfer. The results showed that these nucleobase-ZnO nanostructure layers are promising interface materials for enhancing optoelectronic device performance through interfacial charge transport and light management, while enabling the design of environmentally friendly devices.

Paper-based devices hold great promise in biosensing, but the choice of electrode materials influences performance. Here, we report a paper-based electrochemical sensor developed for nucleic acid quantification, in a sandwich-type architecture integrating 3-electrode systems on metallized electrospun polymeric fibers. A 3D-printed hydrophobic barrier on the chromatographic paper defines injection and testing zones. Fluid diffusion through paper and concentration gradients are considered in the design. Electrochemical characterization is performed using 40 mu L of methylene blue solution, which interacts with double-stranded nucleic acids, reducing its redox activity. This interaction mechanism within the paper substrate is confirmed by spectroscopy. The sensor achieves detection of nucleic acids in 3 min with 2 mu L of solution. Real sample analysis is performed for the quantification of PCR-amplified genes with a limit of detection of 1.38 ng mu L-1. The device serves as a promising point-of-care diagnostics tool for the direct quantification of amplified genetic material.

Although the DPPH (2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl) radical is known for its indefinite stability, both in solid and in solution, and therefore no dimerization reaction occurs, the DPPH-dimer has been obtained by an alternative synthesis. Oxidation of the DPPH-dimer led to the corresponding DPPH-diradical, practically exhibiting all of the known properties of the simple DPPH radical. The structures were confirmed using 1H and 13C NMR, IR, UV-vis, HR-MS, and electron spin resonance (for the diradical) analyses. Additionally, cyclic voltammetry and superconducting quantum interference device (SQUID) measurements were performed to investigate the electrochemical and magnetic properties of the DPPH-diradical. DFT calculations revealed that the ground state was an open-shell singlet. The diradical character y of the ground state and vertical S-T gap were 0.279 and -5.81 kcal mol-1, respectively.

This study aimed to develop and characterise novel hydrogels based on natural bioactive compounds for topical antimicrobial applications. Four gel systems were formulated using different polymers, namely polyacrylic acid (Carbopol 940, CBP-G), chitosan with high and medium molecular weights (CTH-G and CTM-G), and sodium alginate (ALG-G), incorporating tinctures of Verbena officinalis and Aloysia triphylla, Laurus nobilis essential oil, and a beta-cyclodextrin-clove essential oil complex. All gels displayed a homogeneous macroscopic appearance and maintained stability for over 90 days. Rheological studies demonstrated gel-like behaviour for CBP-G and ALG-G, with well-defined linear viscoelastic regions and distinct yield points, while CTM-G exhibited viscoelastic liquid-like properties. SEM imaging confirmed uniform and continuous matrices, supporting controlled active compound distribution. Thermogravimetric analysis (TG-DTA) revealed a two-step degradation profile for all gels, characterised by high thermal stability up to 230 degrees C and near-total decomposition by 500 degrees C. FTIR spectra confirmed the incorporation of bioactive compounds and products and highlighted varying interaction strengths with polymer matrices, which were stronger in CBP-G and CTH-G. Antimicrobial evaluation demonstrated that chitosan-based gels exhibited the most potent inhibitory and antibiofilm effects (MIC = 2.34 mg/mL) and a cytocompatibility assessment on HaCaT keratinocytes showed enhanced cell viability for chitosan gels and dose-dependent cytotoxicity for alginate formulations at high concentrations. Overall, chitosan-based gels displayed the most favourable combination of stability, antimicrobial activity, and biocompatibility, suggesting their potential for topical pharmaceutical use.

We investigate the energy spectrum and transport properties of a diatomic square lattice model that manifest antichiral characteristics. The emergence of antichiral edge states is primarily governed by the relative sign of the next-nearest-neighbor hopping parameters on the two sublattices. However, in finite systems, the atomic structure at the boundaries plays a crucial role in determining whether the system exhibits chiral/antichiral behavior. Using both analytical and numerical methods, we reveal the presence of antichiral edge states in ribbon geometries and emphasize the importance of atomic connectivity at the edges. Extending our analysis, we simulate various finite size geometries to identify which configuration supports antichiral behavior. The transport properties are studied in the Landauer-B & uuml;ttiker approach for a Hall device with four leads. We study the transmittance coefficients, transverse (Hall), and longitudinal resistance by comparing the antichiral versus chiral situations. In particular, the antichiral case shows a vanishing Hall effect and negative longitudinal resistance. The presence of the bulk currents is proved by calculating explicitly the currents on the plaquette and the local density of states in the system with leads. Additionally, we investigate the influence of Anderson disorder on the transmittance coefficients to highlight the reduced robustness of antichiral systems.

This study describes the development of a pyruvate kinase (PyK)-biosensor for the evaluation of PyK activity, as a diagnostic tool for early cancer screening and detection of kinase inhibitors used in cancer treatment, with the evaluation of the inhibition mechanism. The biosensor was constructed by co-immobilizing the enzymes PyK and pyruvate oxidase (PyOx) on Au film electrodes by crosslinking with glutaraldehyde (GA) and evaluated electrochemically by cyclic voltammetry (CV) and fixed potential amperometry (CA). First, the experimental conditions were optimized in terms of applied potential, enzyme ratio PyK:PyOx and enzyme substrate concentration: phosphoenolpyruvate (PEP) and adenosine diphosphate (ADP). The biosensor sensitivity towards PEP detection was 2.11 +/- 0.08 mu A mM- 1 cm- 2, with very high reproducibility and repeatability, which made it suitable for inhibition studies of PyK inhibitor. The inhibition mechanism of shikonin was determined in relation to both PEP and ADP, with the calculation of IC50 values and binding constants (Ki). Detection of shikonin was possible at very low concentrations in the linear range of 0.1-4.0 pM. The electrochemical results were validated by UV-Vis spectrophotometry. The developed biosensor is a valuable tool for drug screening by enabling enzyme catalytic function examination with applicability to identify inhibitors, estimate their affinity, inhibition mechanism linked to their molecular mechanisms of action and evaluate selectivity, of great interest in both pharmaceutical and medical domains.