Project ID:  PN-III-P1-1.2-PCCDI-2017-0062
Project Director:  Dr. George Stan
Project Type: National
Project Program: PCCDI
Funded by: Romanian National Authority for Scientific Research, UEFISCDI
Contractor:  National Institute of Materials Physics
Project Status:  In progress
Start Date: 15 March, 2018
End Date: 15 September, 2020

Project summary:

The project will develop novel conceptual and functional solutions of biomedical devices for treatment, reinforcement/repair/replacement (of human tissues) and diagnosis based on nanostructured and/or biocompatible materials, with high attractivity and certain potential for technology transfer to industry. The experience of the interdisciplinary consortium will allow a passage from concepts of nanomaterials and biomaterials with extended and/or complementary functional features to implementation to new biomedical applications of great interest: (i) antitumoral therapeutic systems (by localized magnetic hyperthermia, photodynamic therapy and drug delivery); (ii) biocompatible compounds with enhanced antimicrobial efficacy; (iii) stent or vein/arterial filters implants based on ferromagnetic shape-memory alloys (with the advantage of repositioning without the need of new invasive interventions); (iv) personalized bone regenerative implants (i.e. porous ceramic scaffolds for bone tissue engineering; dental implants with rapid osseointegration); and (v) (bio)sensors for monitoring the bioavailability of pharmaceutical compounds and detecting the reactive oxygen species and their biologic effect. The synergic development of the institutional capacity of the project partners will be achieved by: creating new jobs and purchasing new equipment and software, providing technical/scientific assistance to the emerging institutions, initiating and fostering collaborations with partners from industry in view of technology transfer, and increasing the international visibility of the involved institutions by capitalizing on the obtained research results. The project will create the core of the first national cluster in the field of healthcare technologies.

  • COMPONENT PROJECT #1: Development of bio-active nanostructures integrated into therapeutic and diagnostic systems

ConsortiumCO - National Institute of Research and Development in Materials Physics, Magurele; P1 - National Institute of Research-Development in the Pathology Domain and Biological Sciences "Victor Babes", Bucharest; P2 - "Carol Davila" University of Medicine and Pharmacy, Bucharest; P3 - "Grigore T. Popa" University of Medicine and Pharmacy, Iasi; P4 - National Institute for Chemical Pharmaceutical Research Development, Bucharest; and P5 - National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca.

General objective: Development of technologies for synthesis, analysis/characterization, testing and optimization of nanostructured systems with adequate properties for use in anti-tumor and anti-infection therapeutic systems.

Specific objectives:

  • Synthesis of Fe3O4, MnFe2O4 and Mn1-xZnxFe2O4 nanoparticles with controlled size, shape and magnetization, metal or metal/oxide nanoparticles and nanoclusters, functionalized vanadium oxide nanoparticles doped with Mn and Fe with controlled superparamagnetism, TiO2 nanoparticles with physico-chemical properties adequate for photodynamic therapy, biocompatible graphene oxide functionalized with polymers conjugated with cytostatic drugs, ZnO and MgO nanoparticles doped with Mn and Fe, functionalized with azole compounds, for anti-infection therapy;
  • Synthesis of hydrogels with photo-oxidative or magnetic properties given by the presence of TiO2 or Fe3O4/γ-Fe2O3 nanoparticles in the polymeric structure of the hydrogels;
  • Assessment of in vitro biological effects of the obtained nanostructures, with focus on the cytotoxic/cytostatic action, generation of oxidative stress, cell internalization;
  • Continuous update the erris.gov.ro platform to make available relevant research services to the public and private actors operating in the scientific/technical fields of the project;
  • Elaboration of the joint RDI program correlated with the institutional development plans of the consortium partners.

 

  • COMPONENT PROJECT #2: Customized implant systems fabricated from advanced biomaterials with multiple biological action

ConsortiumCO - National Institute of Research and Development in Materials Physics, Magurele; P1 - National Institute of Research-Development in the Pathology Domain and Biological Sciences "Victor Babes", Bucharest; P2 - "Carol Davila" University of Medicine and Pharmacy, Bucharest; P3 - "Grigore T. Popa" University of Medicine and Pharmacy, Iasi; P4 - National Institute for Chemical Pharmaceutical Research Development, Bucharest; P5 - National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca; and P6 - University Transilvania Brasov, Brasov.

General objective: developing biomaterials demonstrators for a new generation of implants with potential for transfer to economical sector.

Specific objectives:

  • Fabrication of Fe-Pd shape-memory alloys with anti-thrombogenic/thrombolytic functionalization with applications in cardiovascular medicine;
  • Generation of bioceramic demonstrators based on cation-substituted hydroxyapatite for customized bone scaffold grafts (prepared by additive manufacturing techniques, according to real bone defect models) and / or for dental implants bio-functionalization;
  • Assessment of biofunctional responses (release of therapeutically ions, cytotoxicity, osteogenesis, angiogenesis, scavenging of reactive oxygen species, antimicrobial efficiency) by complex biological in vitro tests;
  • Continuous update the erris.gov.ro platform to make available relevant research services to the public and private actors operating in the scientific/technical fields of the project;
  • Elaboration of the joint RDI program correlated with the institutional development plans of the consortium partners.

 

  • COMPONENT PROJECT #3: New (bio)sensor platforms based on nanostructured functionalized materials for healthcare applications

ConsortiumCO - National Institute of Research and Development in Materials Physics, Magurele; P1 - National Institute of Research-Development in the Pathology Domain and Biological Sciences "Victor Babes", Bucharest; and P6 - University Transilvania Brasov, Brasov.

General objective: Developing selective and sensitive (bio)sensor for (i) monitoring the bioavailability of pharmaceutical compounds, (ii) detecting reactive oxygen species, as well as for (iii) monitoring their effect on living cells and cellular moieties (e.g. proteins, DNA).

Specific objectives:

  • Fabrication and (morpho-structural and electrochemical) characterization of disposable carbon-, graphene-, and nanostructured metal-based electrodes;
  • Functionalization of electrodes with (bio)materials and their structural characterization;
  • Investigation of the biosensors characteristics (reproducibility, stability, interference, etc);
  • Research services offered to the PCCDI consortium partners;
  • Continuous update the erris.gov.ro platform to make available relevant research services to the public and private actors operating in the scientific/technical fields of the project;
  • Elaboration of the joint RDI program correlated with the institutional development plans of the consortium partners.
CO - National Institute of Research and Development in Materials Physics, Magurele
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1George STANSenior researcher IDirector of PCCCDI project

Director of component project #2

2Traian POPESCUSenior researcher IIIDirector of component project #1
3Teodor-Adrian ENACHESenior researcher IIDirector of component project #3
4Cristian-Mihail TEODORESCUSenior researcher IResearch team member
5Victor Eugen KUNCSERSenior researcher IResearch team member
6Daniela PREDOISenior researcher IResearch team member
7Corneliu Florin MICLEASenior researcher IResearch team member
8Luminita AMARANDESenior researcher IIIResearch team member
9Mihaela SOFRONIEResearcherResearch team member
10Marian STEFANSenior researcher IIResearch team member
11Daniela GHICASenior researcher IIResearch team member
12Petru PALADESenior researcher IIResearch team member
13Ovidiu CRISANSenior researcher IResearch team member
14Gabriel SCHINTEIESenior researcher IIResearch team member
15Cornel MICLEASenior researcher IResearch team member
16Mihaela VALEANUSenior researcher IResearch team member
17Monica ENCULESCUSenior researcher IResearch team member
18Lucian TRUPINASenior researcher IIIResearch team member
19Felicia TOLEASenior researcher IIIResearch team member
20Iuliana PASUKSenior researcher IIIResearch team member
21Catalin NEGRILASenior researcher IIIResearch team member
22Irina ZGURASenior researcher IIResearch team member
23Bogdan POPESCUResearcherResearch team member
24Madalina IGNAT BARSANSenior researcher IIIResearch team member
25Victor DICULESCUSenior researcher IResearch team member
26Silviu POLOSANSenior researcher IResearch team member
27Elena MATEISenior researcher IIResearch team member
28Nicoleta PREDASenior researcher IResearch team member
29Mihaela BAIBARACSenior researcher IResearch team member
30Ioana Dorina VLAICUResearcherResearch team member
31Adrian Valentin MARALOIUSenior researcher IIIResearch team member
32Ionel MERCIONIUResearcherResearch team member
33Simona GRECULEASAResearcherResearch team member
34Cezar COMANESCUAssistant researcherResearch team member
35Claudiu CIOBOTARUAssistant researcherResearch team member
36Corina CIOBOTARUResearcherResearch team member
37George Adrian LUNGUResearcherResearch team member
38Adrian-Claudiu POPAASenior researcher IIIResearch team member
39Cristina BESLEAGA STANSenior researcher IIIResearch team member
40Carmen Steluta CIOBANUSenior researcher IIIResearch team member
41Simona Liliana ICONARUResearcherResearch team member
42Liliana Marinela BALESCUResearcherResearch team member
43Marius Cristian CIOANGHERResearcherResearch team member
44Andreea Liliana COSTASResearcherResearch team member
45Camelia Florina FLORICASenior researcher IIIResearch team member
46Mihaela BEREGOIAssistant researcherResearch team member
47Malvina STROEAssistant researcherResearch team member
48Andrei Cristian KUNCSERResearcherResearch team member
49Andreea Alexandra NILAAssistant researcherResearch team member
50Adelina MATEAAssistant researcherResearch team member
51Ion SMARANDAAssistant researcherResearch team member
52Mirela ILIEAssistant researcherResearch team member
53Alexandru Ionut EVANGHELIDISAssistant researcherResearch team member
54Cristina Ioana BUCURAssistant researcherResearch team member
55Monica DAESCUAssistant researcherResearch team member
56Cristina MOZACEANUAssistant researcherResearch team member
57Stefan BULATEngineerResearch team member
58Aurel LECAEngineerResearch team member
59Nicusor IACOBEngineerResearch team member
60Gabriel DOBRESCUEngineerResearch team member
61Mihai CIOCAEngineerResearch team member
62Vasilica TOMATechnician IResearch team member
63Catalin RADULESCUTechnician IResearch team member
64Ion LUTEATechnician IResearch team member
Newly employed researchers through the PCCDI program
IAnca-Gabriela COMANAssistant researcherResearch team member
IITeddy Martial TITESenior researcher IIIResearch team member
IIIMihaela-Cristina BUNEAAssistant researcherResearch team member

 

P1 - National Institute of Research-Development in the Pathology Domain and Biological Sciences "Victor Babes", Bucharest
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1Cristiana TANASEProfessor

Senior researcher I

P1 Responsible of PCCCDI project

Responsible of component projects #2 & #3

2Andreea-Roxana LUPUSenior researcher IIIResponsible of component project #1
3Monica Teodora NEAGUSenior researcher IIIResearch team member
4Radu Nicolae Aurel ALBULESCUSenior researcher IResearch team member
5Carolina CONSTANTINSenior researcher IIResearch team member
6Sevinci POPSenior researcher IIIResearch team member
7Ionela Victoria NEAGOEResearcherResearch team member
8Ana-Maria ENCIUSenior researcher IIIResearch team member
9Mihnea NICOLESCUSenior researcher IIIResearch team member
10Elena CODRICISenior researcher IIResearch team member
11Ionela Daniela POPESCUSenior researcher IIIResearch team member
12Simona MIHAIResearcherResearch team member
13Lucian ALBULESCUAssistant researcherResearch team member
14Nicoleta Cornelia CONSTANTINTechnician IResearch team member
15Mariana BURGHELEATechnician IResearch team member
Newly employed researchers through the PCCDI program
IMaria DUDAUAssistant researcherResearch team member

 

P2 - "Carol Davila" University of Medicine and Pharmacy, Bucharest
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1Georgeta Mihaela MOISESCUAssociate professorP2 Responsible of PCCCDI project

Responsible of component projects #1 & #2

2Tudor SAVOPOLProfessorResearch team member
3Eugenia KOVACSProfessorResearch team member
4Violeta Liuba CALINAssistant professorResearch team member
5Mircea Bogdan MATEIAssistant professorResearch team member
6Luminita-Claudia MICLEAAssistant researcherResearch team member
Newly employed researchers through the PCCDI program
IVacant positionAssistant researcherResearch team member
IIVacant positionAssistant researcherResearch team member

 

P3 - "Grigore T. Popa" University of Medicine and Pharmacy, Iasi
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1Alexandru CHIRIACAssociate professorP3 Responsible of PCCCDI project

Responsible of component projects #1 & #2

2Ion POEATAProfessorResearch team member
3Bogdan ILIESCUAssistant professorResearch team member
4Giorgiana IONPhD studentResearch team member
5Mihaela COSMANPhD studentResearch team member

 

P4 - National Institute for Chemical Pharmaceutical Research Development, Bucharest
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1Misu MOSCOVICISenior researcher IP4 Responsible of PCCCDI project

Responsible of component project #2

2Angela CASARICASenior researcher IIResponsible of component project #1
3Sultana NITASenior researcher IResearch team member
4Nicoleta RUSUSenior researcher IIIResearch team member
5Ileana PARASCHIVSenior researcher IResearch team member
6Domnica RUGHINISSenior researcher IIResearch team member
7Corina BUBUEANUSenior researcher IIResearch team member
8Ioana NICUResearcherResearch team member
9Ionica BEJENARUAssistant researcherResearch team member
10Daniela DIMAAssistant researcherResearch team member
11Cristina BAZDOACATechnician IResearch team member
12Silvia PREDATechnician IResearch team member
Newly employed researchers through the PCCDI program
IVacant positionAssistant researcherResearch team member
IIVacant positionAssistant researcherResearch team member

 

 

P5 - National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1Rodica Paula TURCUSenior researcher IP5 Responsible of PCCCDI project

Responsible of component projects #1 & #2

2Alexandrina Emilia NANSenior researcher IIResearch team member
3Maria Teodora RADUSenior researcher IIResearch team member
4Izabell CRACIUNESCUSenior researcher IIIResearch team member
5Anca Cristina PETRANSenior researcher IIIResearch team member
6Monica Violeta CIRCUSenior researcher IIIResearch team member
7Alexander BUNGESenior researcher IIIResearch team member
8Cristian LEOSTEANSenior researcher IIIResearch team member
9Iolanda Veronica GANEAAssistant researcherResearch team member
10Ildiko MACAVEITechnician IResearch team member
11Sorina CIUPETechnician IResearch team member
Newly employed researchers through the PCCDI program
IFran NEKVAPILAssistant researcherResearch team member

 

 

P6 - University Transilvania Brasov, Brasov
No./crt.Name SURNAMEFUNCTIONPROJECT ROLE
1Monica FLORESCUAssociate professorP6 Responsible of PCCCDI project

Responsible of component project #3

2Sorin Ion MUNTEANUAssociate professorResponsible of component project #2
3Tibor BEDOAssociate professorResearch team member
4Daniel MUNTEANUProfessorResearch team member
5Mihai Alin POPSenior researcher IIResearch team member
6Maria STOICANESCUAssociate professorResearch team member
7Ioan MILOSANProfessorResearch team member
8Marius Alexandru MOGAProfessorResearch team member
9Marius VOLMERAssociate professorResearch team member
10Daniel CRISTEAAssociate professorResearch team member
11Sebastian Ionut TOMAAssistant professorResearch team member
12Ioana MANEATechnician IResearch team member
13Adrian SERBANTechnician IResearch team member
Newly employed researchers through the PCCDI program
IIoana POPESCUAssistant researcherResearch team member
IIMelinda DAVIDAssistant researcherResearch team member

 

  • 2018: THE SYNTHETIC SCIENTIFIC REPORT no. 1 in .pdf format is available at UEFISCDI, and can be accessed by request.

The complex project 58PCCDI/2018 allowed, in the first stage of execution of its three component projects PC), the correlation and coordination of resources and expertise of seven National Research Institutions with complementary specialization profiles, aiming to the synergistic cooperation in the multidisciplinary field of nanomaterials and biomaterials for medical applications.Stage I of PC1 targeted to delineate nanostructures with magnetic (e.g. Fe3O4, MnFe2O4, ZnFe2O4, Co-Pt bimetallic particles), photo-oxidative (e.g. TiO2), antimicrobial (e.g. ZnO, MgO) and/or surface chemistry (functionalized GO) properties, appropriate for antitumor hyperthermia, photodynamic therapy, anti-infectious therapies and controlled release of cytostatic drugs, respectively, and preliminary evaluation of their morpho-structural, magnetic and cytotoxic characteristics. General methods to determine cytotoxicity, oxidative stress, cellular internalization, anti-thrombogenicity and antimicrobial efficacy have been adapted for testing nanoparticles. The experimental setups and working parameters required for hyperthermia measurements and determination of reactive oxygen species in acellular systems have been established. Preliminary tests for hyperthermia and photogeneration of reactive oxygen species were conducted for suspensions of magnetic and TiO2 nanoparticles, respectively, together with the primary evaluation of their cytotoxicity. In this way the objectives and result indicators of stage I of PC2 were fulfilled, constituting the basis for the complex interdisciplinary studies scheduled for the next stages.Stage I of PC2, allowed to combine the scientific literature documentation of the most recent topical advancements with preparation experiments and physico-chemical investigations, such as to develop synthesis methods for doped hydroxyapatite (HA), barium titanate (BT) and shape-memory ferro-magnetic alloys based on Fe-Pd. The consortium partners have closely collaborated to design the in vitro testing system for cellular behavior under mechanical stress conditions for piezoelectric materials, to define a method for the translation of 3D bone defects (based on computed tomography scans) to customized implants designs fit for additive manufacturing fabrication, and to adapt methods for the study of cytotoxicity, anti-thrombogenicity/thrombolysis, antimicrobial efficacy, reduction of ROS species, and angiogenesis capacity of biomaterials in the form of powders, pellets, scaffolds and thin films. Appropriate preparation techniques were used to obtain series of pure and doped HA samples (with Sr, Mg, Zn, Ce, Si/Mg/Zn), BT, BT-HA, and FePd substituted with Mn or Ga. Based on the multi-parametric morphological, compositional, structural, electrical and magnetic/magnetorestrictive analyses, specific to each class of materials, the most promising type of samples were selected for preliminarily biological assessments: (where appropriate) degradation tests, therapeutic ion release rate determinations and/or cytocompatibility. Correlation of the results of the functional and physico-chemical tests has made it possible to define the most promising biomaterials, whose potential will be explored exhaustively in the next stages of the project. We conclude that the milestones and performance indicators for the stage I of PC2 have been fully attained. Stage I of PC3 was dedicated to the manufacture and characterization of nanostructured carbon and metal electrodes and their testing in simple environments and/or in the presence of different biomedical analytes. Five types of electrodes were manufactured and characterized by voltammetry, SEM and EDXS: gold electrodes deposited on Ti/SiO2/Si, electrodes manufactured by photolithography on SiO2@Si substrates, composites based on carbon black and cellulose acetate and screen-printed electrodes modified with CB, Pd particles on carbon, or reduced graphene oxide (RGO). Furthermore, gold sensors for surface plasmon resonance (SPR) measurements have also been manufactured. The used analytes were: hydrogen peroxide, oxygen, methionine, thyroxine, azathioprine and deoxyribonucleic acid (DNA). It has been demonstrated that both hydrogen peroxide and oxygen can be detected by using gold surfaces as working electrodes, while the oxidation mechanisms of thyroxine and methionine have been identified. The redox processes and adsorption of azathioprine on the surface of RGO-modified electrodes have been investigated by voltammetry and Raman spectroscopy studies. DNA biosensors have been obtained by DNA surface modification of the glassy carbon, CB, and Pd based electrodes. The objectives and result indicators of PC3 were fully achieved.The results of the stage I of the PCCDI complex project allowed the consortium institutions to structure their research/technology services offers on the ERRIS platform, and thus, making them publicly accessible at international level. Technological sheets (for key laboratory products, methods or technologies) have been disseminated on the project website (http://infim.ro/en/project/sanomat/), as well as uploaded on the UEFISCDI EVOC platform.

IC:

  • 2018: Mihaela-Monica MANGA, Master of Science, 2nd year of study, student ID: 4743057, Technical University of Dresden, Germany performed at NIMP (2018.09.04 – 2018.09.14) a “Lab Rotation” work-stage entitled “SYNTHESIS AND CHARACTERIZATION OF SIMPLE AND CERIUM-DOPED HYDROXYAPATITE MATERIALS FOR BIOMEDICAL APPLICATIONS", under the coordination of Dr. George Stan (58PCCDI/2018 project director).

P2:

  • 2018: Ramona Elena TOADER, Master of Medical Biophysics and Cellular Biotechnology, 2nd year of study, student ID: 258, Carol Davila University of Medicine and Pharmacy, started on October 1st 2018, the experimental work stage entitled “EVALUATION OF CYTOTOXICITY EFFECTS OF Zn/Mg OXIDE-BASED NANOPARTICLES ON CELLULAR MALIGNANT MODELS”, under the coordination of Assoc. Prof. Mihaela G. Moisescu (58PCCDI/2018, Director of Partner 2), project duration: October 1st 2018 - May 31st 2019;
  • 2018:  Aurelia-Cristina POTEACĂ (VIȘAN), Master of Medical Biophysics and Cellular Biotechnology, 2nd year of study, student ID: 256, Carol Davila University of Medicine and Pharmacy, started on October 1st 2018, the experimental work stage entitled “STUDY ON BIOCOMPATIBILITY OF BIO-ACTIVE NANOPARTICLES ON NORMAL CELLULAR MODELS”, under the coordination of Assoc. Prof. Mihaela G. Moisescu (58PCCDI/2018, Director of Partner 2), project duration: October 1st 2018 - May 31st 2019;
  • 2018: Alexandra DOCAN (DINU), Master of Medical Biophysics and Cellular Biotechnology, 2nd year of study, student ID: 252, Carol Davila University of Medicine and Pharmacy, started on October 1st 2018, the experimental work stage entitled “EVALUATION BY WIDE-FIELD AND FLUORESCENCE MICROSCOPY OF CELL ADHESION ON THIN METALLIC FILMS”, under the coordination of Assist. Prof. Violeta Calin (58PCCDI/2018, Team member of Partner 2) and supervision of Assoc. Prof. Mihaela G. Moisescu (58PCCDI/2018, Director of Partner 2), project duration: October 1st 2018 - May 31st 2019.

 

COMPONENT PROJECT #1: Development of bio-active nanostructures integrated into therapeutic and diagnostic systems

Web of Science® articles - published or accepted:

  • 01. A. Bunge^,*, A.S. Porav, G. Borodi, T. Radu^, A. Pirnau, C. Berghian-Grosan, R. Turcu^*, Correlation between synthesis parameters and properties of magnetite clusters prepared by solvothermal polyol method; J MATER SCI 54 (2019) 2853;  WOS:000452502500009.
  • 02. D. Ghica^, I.D. Vlaicu^, M. Stefan^,*, V.A. Maraloiu^, A.C. Joita, C. Ghica, Tailoring the dopant distribution in ZnO:Mn nanocrystals; SCI REP  9 (2019) 6894; DOI:10.1038/s41598-019-43388-z.

Web of Science® papers - submitted for evaluation:

  • 03. N. Iacob^, A. Kuncser^, C. Comanescu^, G. Schinteie^, V. Kuncser^,*, Optimization of magnetic fluid hyperthermia with respect to shape anisotropy contributions. Case of Fe3O4 ellipsoidal nanoparticlessubmitted for evaluation to EUR PHYS J E (2018); ref. no.: e180273.

Manuscripts in preparation:

  • 04. T. Popescu^,*, A.V. Maraloiu^, A. Rostas, I.D. Vlaicu^, L. Diamandescu, M. Feder, M.C. Ilas, S. Cretu, Morpho-structural, hyperthermic, photodynamic and cytotoxic properties of iron oxide-TiO2 nanocomposites, in preparation.

Books/Book chapters:

  • 01. A.R. Lupu^,*, T. Popescu^, M. Stojanović, Therapeutic use of inorganic nanomaterials in malignant disease, In: Environmental Nanotechnology – Volume 3, N. Dasgupta, S. Ranjan, E. Lichtfouse (Eds.), Springer Nature, Switzerland, 2018, accepted for publication.

International Conferences:

  • 01. R. Turcu^, A. Nan^, I. Craciunescu^, M. Suciu, T. Radu^, C. Leostean^, I. Ardelean, Tailoring the properties of core-shell magnetic nanostructures for biomedical applications; Applied Nanotechnology and Nanoscience International Conference, 22-24 October 2018, Berlin, Germany (poster presentation).
  • 02. V. Kuncser^, Main concerns related to the magnetic actuation of nanoparticulate systems for bio-medical applications, RADIOMAG Annual Action Progress Conference & MC meeting, 22-23 March 2018, Timisoara, Romania (invited lecture).
  • 03. N. Iacob^, A. Kuncser^, V. Kuncser^, Magnetic fluid hyperthermia related issues by numerical simulations using dedicated softwares, The 18th International Balkan Workshop on Applied Physics and Materials Science, 10-13 July 2018, Constanta, Romania (poster presentation).

COMPONENT PROJECT #2: Customized implant systems fabricated from advanced biomaterials with multiple biological action

Web of Science® articles - published or accepted:

  • 01. D. Predoi*,^, S.L. Iconaru^, M.V. Predoi, Bioceramic layers with antifungal propertiesCOATINGS 8 (2018) 276; WOS:000443252300021.
  • 02. T. Tite^, A.C. Popa^, L.M. Balescu^, I.M. Bogdan, I. Pasuk^, J.M.F. Ferreira*, G.E. Stan*,^, Cationic substitutions in hydroxyapatite: current status of the derived biofunctional effects and their in-vitro interrogation methodsMATERIALS 11 (2018) 2081; WOS:000451755500016.
  • 03. C.C. Negrila^, M.V. Predoi, S.L. Iconaru^, D. Predoi*,^, Development of zinc-doped hydroxyapatite by sol-gel method for medical applications; MOLECULES 23 (2018) 2986; WOS:000451641900258.
  • 04. F. Tolea*,^, M. Sofronie^, Martensitic transformation and related properties of Fe69.4Pd30.6 ferromagnetic shape memory ribbons; J OPTOELECTRON ADV MATER 20 (2018) 701; WOS:000454619400020.
  • 05. A.C. Mocanu, G.E. Stan*,^, A. Maidaniuc, M. Miculescu, I.V. Antoniac, R.C. Ciocoiu, S.I. Voicu, V. Mitran, A. Cimpean, F. Miculescu*, Naturally-derived biphasic calcium phosphates through increased phosphorous-based reagent amounts for biomedical applications; MATERIALS 12 (2019) 381; WOS:000460768000050.

Web of Science® papers - submitted for evaluation:

  • 06. M. Sofronie^, B. Popescu^, M. Enculescu^, A.D. Crisan, F. Tolea^, The influence of Mn substitution on the structural, magnetic and magnetostrictive properties of Fe-Pd melt-spun ferromagnetic shape memory ribbons; submitted for evaluation to ROM J PHYS (2018).
  • 07. M. Sofronie^, F. Tolea^, M. Tolea^, B. Popescu^, M. Valeanu^, Magnetic and magnetostrictive properties of the ternary Fe67.5Pd30.5Ga2 ferromagnetic shape memory ribbons; submitted for evaluation to J ALLOYS COMPD (2018).

Manuscripts in preparation:

  • 08. G. Pelin-Popescu, C. Ristoscu, L. Duta, G.E. Stan^, I. Pasuk^, T. Tite^, M.S. Stan, C. Bleotu, M. Popa, M.C. Chifiriuc, F.N. Oktar, A. Nicarel, I.N. Mihailescu, Antimicrobial and biocompatible hydroxyapatite-alumina-zeolite composite coatings synthesized by pulsed laser deposition from low-cost sustainable natural resourcesin preparation.

Web of Science® conference proceedings:

  • 01. M. Sofronie^, B. Popescu^, A.D. Crisan, A.R. Lupu^, F. Tolea^, M. Valeanu^, Magnetoelastic properties in polycrystalline Fe-Pd based ferromagnetic shape memory alloy;  IOP CONF SER–MATER SCI ENG 485 (2019) 012026; DOI:10.1088/1757-899X/485/1/012026.

International Conferences:

  • 01. M. Sofronie^, B. Popescu^, A.D. Crisan, A.R. Lupu^, F. Tolea^, M. Valeanu^, Magnetoelastic properties in polycrystalline Fe-Pd based ferromagnetic shape memory alloy; The 8th Conference on Material Science & Engineering (UgalMat 2018), 11-13 October 2018, Galati, Romania (poster presentation).

 

COMPONENT PROJECT #3: New (bio)sensor platforms based on nanostructured functionalized materials for healthcare applications

Web of Science® papers - published or accepted:

  • 01. V.C. Diculescu^, T.A. Enache*,^, Voltammetric and mass spectrometry investigation of methionine oxidation; J ELECTROANAL CHEM 834 (2019) 124; WOS:000457507900016.
  • 02. M. David^, A. Serban^, C.V. Popa, M. Florescu*,^, A nanoparticle-based label-free sensor for screening the relative antioxidant capacity of hydrosoluble plant extracts, SENSORS 19 (2019) 590; WOS:000459941200153.

International Conferences:

  • 01. T.A. Enache^, V.C. Diculescu^, Protein carbonyl electrichemical detection; The 5th Edition of International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences (IC-ANMBES), 23-25 May 2018, Brasov, Romania (oral presentation).
  • 02. T.A. Enache^, M. Enculescu^, V.C. Diculescu^, Prion protein: Voltammetric and scanning electron microscopy characterization; The 17th International Conference on Electroanalysis, 3-7 June 2018, Rhodos, Greece (poster presentation).
  • 03. T.A. Enache^, V.C. Diculescu^, Electrochemical sensor for carbonylated protein detection; The 69th Annual Meeting of the International Society of Electrochemistry, 2-7 September 2018, Bologna, Italy (poster presentation).
  • 04. M. Florescu^, M. David^, A. Serban^, Evaluation of electrochemical nanosensors as reliable detection tool of thyroxine; Applied Nanotechnology and Nanoscience International Conference – ANNIC 2018, 22-24 October 2018, Berlin, Germany (poster presentation).
  • 05. A. Serban^, S. Toma^, M. Moga^, M. Florescu^, The prevalence of cancers and hormone replacement therapy; The 5th Edition of International Conference on Analytical and Nanoanalytical Methods for Biomedical and Environmental Sciences (IC-ANMBES), 23-25 May 2018, Brasov, Romania (poster presentation).

 

*corresponding author

^project team member

The research / technological services generated by the 58PCCDI consortium were disseminated/can be accessed on the ERRIS (Engage in the Romanian Research Infrastructures System) platform:

Furthermore the technological sheets for the laboratory products, methods or technologies, elaborated in the framework of the component projects, are presented herein under:

GEORGE E. STAN, PhD in Materials Engineering

Senior Researcher I

Telephone: +40-(0)21-2418 128 or +40-(0)21-2418 153

Department: Laboratory of Multifunctional Materials and Structures



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