Publications

In this work, we report a photodegradation process of azathioprine (AZA) highlighted by correlated studies of photoluminescence (PL) and the UV-VIS and IR absorption spectroscopy. The photodegradation process of AZA is observed by the gradual increasing in the intensity of the PL spectrum recorded under the excitation wavelength of 300 nm. This behaviour is accompanied, in the photoluminescence excitation (PLE) spectra, by a gradual intensity decreasing of the PLE band situated in the 250-320 nm spectral range simultaneous with the intensity increasing of the PLE band localized in the 325-425 nm spectral range. Regardless if the immunosuppressive compound is in the state of powder, tablet or solution, the PL and UV-VIS absorption spectroscopy studies have demonstrated that a photodegradation process under UV light takes place. According to the PL studies carried out in ambient and vacuum condition, the photodegradation process of AZA was demonstrated to be influenced by the oxygen from air. The presence of a new IR band with maximum at 1745 cm(-1) confirms the AZA photodegradation pathway proposed in this work.

Semiconducting metal oxide (SMOX)-based gas sensors are indispensable for safety and health applications, for example, explosive, toxic gas alarms, controls for intake into car cabins, and monitor for industrial processes. In the past, the sensor community has been studying polycrystalline materials as sensors where the porous and random microstructure of the SMOX does not allow a separation of the phenomena involved in the sensing process. This led to conduction models that can model and predict the behavior of the overall response, but they were not capable of giving fundamental information regarding the basic mechanisms taking place. The study of epitaxial layers is a definite improvement, allowing clarifying the different aspects and contributions of the sensing mechanisms. A detailed analytical model of the transduction function for n- and p-type single-crystalline/compact metal oxide gas sensors was developed that directly relates the conductance of the sample with changes in the surface electrostatic potential. Combined dc resistance and work function measurements were used in a compact SnO2(101) layer in operando conditions that allowed us to check the validity of our model in the region where Boltzmann approximation holds to determine the surface and bulk properties of the material.

Luminescent europium-doped hydroxylapatite (Eu(X)HAp) nanomaterials were successfully obtained by co-precipitation method at low temperature. The morphological, structural and optical properties were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR), UV-Vis and photoluminescence (PL) spectroscopy. The cytotoxicity and biocompatibility of Eu(X)HAp were also evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)) assay, oxidative stress assessment and fluorescent microscopy. The results reveal that the Eu3+ has successfully doped the hexagonal lattice of hydroxylapatite. By enhancing the optical features, these Eu(X)HAp materials demonstrated superior efficiency to become fluorescent labelling materials for bioimaging applications.

In the case of DEMO fusion reactor, the divertor should be able to extract a steady heat flux of about 10 MW/m(2). A promising concept is the W-monoblock which should be connected to a CuCrZr or an advanced Cu ODS alloy pipe passing through the W component. Taking into account the optimum operating temperature windows for W and existing Cu-based alloys and the thermal expansion coefficients mismatch of these two materials, a "thermal barrier" interface material is inserted in between in order to mitigate the thermal stresses and to optimize the heat flow through divertor components. In this work we investigate the feasibility to realize such divertor components using materials produced by FAST (field assisted sintering technology). This powder metallurgy technique was used firstly to produce W or W-based composites and the thermal barriers in an almost final shape and then to join the materials in realistic divertor mock-ups. The thermal barrier materials are various Cu-based composites which are included both as single material or as functionally graded components. The interface quality between different materials is investigated by scanning electron microscopy and the heat flow through components is evaluated using simulations.

The influence of the injection of minority charge carriers on the formation of a divalent bistable defect (DBH) having two energy levels of E-v + 0.44 eV and E-v + 0.53 eV in its metastable configuration is investigated. Using forward current injection, the formation temperature of this defect in p-type silicon can be lowered by about 50 degrees C. The production of such bistable defect is enhanced in materials with a high ratio of boron to carbon concentrations. This allows one to conclude that the boron atom is one of the constituents of the defect under study. There is also a correlation between the behavior of the bistable hole traps and a metastable electron trap observed earlier. It is concluded that these traps are related to metastable and stable configurations of the DBH defect, which has inverse occupancy level ordering in its stable configuration.

In this study, CuxCrFeTiV (x = 0.21, 0.44, 1 and 1.7 M ratio) high entropy alloys have been devised for thermal barriers between the plasma facing tungsten tiles and the copper-based heat sink in the first wall of nuclear fusion reactors. The high entropy alloys were produced by ball milling the elemental powders, followed by consolidation with spark plasma sintering. Irradiation of the equiatomic CuCrFeTiV sample was carried out at room temperature with Ai(+) (300 keV) beams with a fluence of 3 x 10(20) at/m(2). Structural changes prior and after irradiation were investigated by scanning electron microscopy, coupled with energy dispersive X-ray spectroscopy, X-ray diffraction and thermal diffusivity. Preliminary results showed the presence of heterogenous and multiphasic microstructures in all samples. Moreover, with the increase of the Cu content it is possible to observe the formation of Cu-rich structures. The diffractogram of the CuCrFeTiV sample revealed major peaks of a BCC crystal structure and minor peaks of a FCC crystal structure. In addition, after irradiation no modifications in the CuCrFeTiV microstructure or in the diffractogram were observed.

Formation peculiarities of highly-doped (Y(0.86)La(0.09)Vb(0.05))(2)O-3 transparent ceramics have been studied by X-ray diffraction and electron microscopy methods. The phase composition evolution of 1.81Y(2)O(3).0.18La(2)O(3)0.01Yb(2)O(3) powder mixtures annealed at the temperatures of 1100, 1200, 1300, and 1400 degrees C has been studied by XRD. It has been shown that Yb2O3 phase dissolves in Y2O3 matrix in the calcination temperature range of 1300-1400 degrees C. Complete dissolution of La2O3 in Y2O3 matrix occurs at temperatures above 1400 degrees C. La3+ ions enter in Y2O3 and Yb2O3 crystal structures simultaneously in the 1200-1300 degrees C range, which leads to a remarkable increase in the volume of the corresponding crystal lattices. The possible reasons for suppressing the crystalline growth of Y2O3 and Yb2O3 cubic phases have been discussed. Finally, (Y(0.86)La(0.09)Vb(0.05))(2)O-3 transparent ceramics have been obtained by solid-state vacuum sintering at 1650-1750 degrees C. Ceramics synthesized at a temperature of 1750 degrees C have been characterized by an in-line optical transmittance of 60% and a homogeneous distribution of constituent components within the volume and along the grain boundaries.

We reported on three-dimensional (3D) superparamagnetic scaffolds that enhanced the mineralization of magnetic nanoparticle-free osteoblast cells. The scaffolds were fabricated with submicronic resolution by laser direct writing via two photons polymerization of Ormocore/magnetic nanoparticles (MNPs) composites and possessed complex and reproducible architectures. MNPs with a diameter of 4.9 +/- 1.5 nm and saturation magnetization of 30 emu/g were added to Ormocore, in concentrations of 0, 2 and 4 mg/mL. The homogenous distribution and the concentration of the MNPs from the unpolymerized Ormocore/MNPs composite were preserved after the photopolymerization process. The MNPs in the scaffolds retained their superparamagnetic behavior. The specific magnetizations of the scaffolds with 2 and 4 mg/mL MNPs concentrations were of 14 emu/g and 17 emu/g, respectively. The MNPs reduced the shrinkage of the structures from 80.2 +/- 5.3% for scaffolds without MNPs to 20.7 +/- 4.7% for scaffolds with 4 mg/mL MNPs. Osteoblast cells seeded on scaffolds exposed to static magnetic field of 1.3 T deformed the regular architecture of the scaffolds and evoked faster mineralization in comparison to unstimulated samples. Scaffolds deformation and extracellular matrix mineralization under static magnetic field (SMF) exposure increased with increasing MNPs concentration. The results are discussed in the frame of gradient magnetic fields of similar to 3 x 10(-4) T/m generated by MNPs over the cells bodies.

The present work reports on the effect of slow charged ions irradiation on the structural and magnetic properties of zinc ferrite nanoparticles obtained by coprecipitation method. Results from both the x-ray and Fourier Transform Infrared Spectroscopies confirm the formation of the spinel phase. The structural investigation using x-rays reveals no significant impurity peak and a crystallite size of 9 nm. Particle size of pristine sample is determined to be around 9 nm. Crystallinity and magnetic properties of ferrite sample investigated before and after irradiation process show that electronic excitations inside the material alter the magnetic parameters. Mossbauer Spectroscopy measurements indicate that a fluence of 3*10(14) ions cm(-2) Ne8+ ions of 90 keV are sufficient to induce cation redistribution into zinc ferrite nanoparticles.

W-laminates are multi layered composites realized from alternately stacked W and a second metal foils. Such materials are promising candidates for W-based structural materials for fusion reactors like DEMO or beyond concepts, due to the fact that cold-rolled ultrafine-grained thin W foils show exceptional properties in terms of ductility, toughness and ductile to brittle transition (DBT), in contrast to classic bulk W materials. Therefore, different routes to transfer the W foils properties to bulk materials have been investigated. In this work we present the results obtained for W-Cu laminates produced via a FAST (Field Assisted Sintering Technique) joining route. The main advantages of FAST resides in the short processing time, with subsequent lower recrystallization detrimental effects. Structural and thermophysical properties show that the best materials are obtained for about 100 mu m thick W foils and 50-100 mu m thick Cu foils, while tensile and Charpy impact tests results show that the FAST processed W-Cu laminates are similar to the W-Cu laminates obtained by diffusion bonding.